Friday, July 31, 2015

Pluto: Fly-by





New Horizons

is an interplanetary space probe that was launched as part of NASA's New Frontiers program.[1] Engineered by the Johns Hopkins UniversityApplied Physics Laboratory (APL) and the Southwest Research Institute (SwRI) in BOULDER CO, with a team led by S. Alan Stern, the spacecraft was
launched to study Pluto, its moons and the Kuiper belt, performing flybys of the Pluto system and one or more other Kuiper belt objects (KBOs)

In Perspective

 



New Horizons Probe's July 14 Pluto Flyby

http://www.space.com/29850-new-horizons-pluto-flyby-complete-coverage.html#ooid=Z5dm42djoAo4wLFM1eKW5LlHE10S2xKy



Its close approach: the day of









Extreme mountains and ice flows


Thursday, July 02, 2015

ALS Ice Bucket Challenge 2.0

This August... And Every August, Until There is a Cure

 #‎ALSIceBucketChallenge‬

Nearly one year ago the ALS Ice Bucket Challenge took the world by storm. Thanks to the viral phenomenon, millions of people were introduced to ALS and took a stand against this disease. Your ice Bucket challengeoutpouring of support has made a profound impact on the quest for a cure and has helped to improve the quality of life for those with ALS and their families.

So much good work happened this year, as a result of your efforts, but it is just the beginning! The ALS Ice Bucket Challenge is coming back this August, and every August until there's a cure!

You can be the voice for those who have lost the ability to speak. Picture 29You can fill that bucket ICE or with a drought conscious alternative (be creative), and lift it over your head for the thousands who cannot move their arms. You can spread the word on social media and show your friends and family that you won’t stop until ALS is stopped.

YOU have the ultimate power to make a difference in the fight against ALS.

Thank you for taking the lead. Donations at:  http://www.childsfamily.us
     
Sincerely,

Roger

Friday, November 14, 2014

ALS battle continues after Ice Bucket Challenge fades

Ohio area families discuss the devastation of watching a loved one disappear a little at a time thanks to ALS. amyotrophic lateral sclerosis affects 30,000 Americans, an estimated 800 in Ohio. (371 in Co.)

ALS is a cruel illness. Not only to its victims, but to their families. Just ask anyone who has witnessed its devastation or lived it.

“The experience of ALS can quickly make you realize what each of us takes for granted each day,” said Jill Leo, whose husband, Chris, died in March following a seven-year struggle with amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease.

“Playing catch or soccer in the backyard with your son, taking a walk, a hand-written note, driving a car, mowing your lawn or dialing the phone to talk to a friend. These are just a few things we take for granted that most ALS patients cannot do after the disease progresses.”

The viral Ice Bucket Challenge that swept the globe during the late summer has helped raise awareness and, according to the ALS Association, more than $115 million since July 29.

Those familiar with the disease are grateful for the wave of attention, but the battle against it continues.

Vicki Evans has watched her husband, Tim, deteriorate over 16 years. Diagnosed with ALS in 1998, he has been fighting the disease since, and it has taken its toll.

“Every case is different,” she said. “In 2009, he fell and hyper-extended his knee. His ALS was making it more and more difficult for him to walk. He started using a walker, then gradually, he started losing the use of his hands.”

Evans is now in a wheelchair and no longer has the use of his hands.

“You cannot dwell on your situation,” said Evans, 58, who had to go on disability. As an estimator for the Knoch Corp., he was able to work at home part-time for awhile after his diagnosis, but he said he was laid off in 2005 along with others when the economy took a downward turn. The Knoch Corp. sponsors the Tim Evans AGC (Associated General Contractors) Scholarship each year in his honor.

“Every once in a while, I throw myself a pity party, but I have to go on. I think having a positive attitude is one of the reasons I continue to go on. Not being able to do the daily chores anymore or do what I used to do does get to you.”

Once Canton’s safety director, Paul Bair was diagnosed with ALS earlier this year.

“He is weak,” said his wife, Darlene. “He is in no pain, but he coughs a lot because his lungs and diaphragm are weakened. He is on several machines to keep his lungs clear, but his ALS is progressing quickly.”

Sunday, August 31, 2014

Cause of ALS may be found, Northwestern team says… hmmm, keep up the research!

18 yrs old

Dr. Teepu Siddique, a neurologist at Northwestern University's Feinberg School of Medicine, is a member of the team that discovered a common possible cause for all forms of ALS.

Drug ResearchScientific ResearchMedical ResearchNorthwestern UniversityAlzheimer's Disease

Dr. Teepu SiddiqueResearchers at Northwestern University say they have discovered a common cause behind the mysterious and deadly affliction of amyotrophic lateral sclerosis, or Lou Gehrig's disease, that could open the door to an effective treatment.

Dr. Teepu Siddique, a neuroscientist with Northwestern's Feinberg School of Medicine whose pioneering work on ALS over more than a quarter-century fueled the research team's work, said the key to the breakthrough is the discovery of an underlying disease process for all types of ALS.

2008-07-05 19.11.24

The discovery provides an opening to finding treatments for ALS and could also pay dividends by showing the way to treatments for other, more common neurodegenerative diseases such as Alzheimer's, dementia and Parkinson's, Siddique said.

The Northwestern team identified the breakdown of cellular recycling systems in the neurons of the spinal cord and brain of ALS patients that results in the nervous system slowly losing its ability to carry brain signals to the body's muscular system.

Without those signals, patients gradually are deprived of the ability to move, talk, swallow and breathe.

"This is the first time we could connect (ALS) to a clear-cut biomedical mechanism," Siddique said. "It has really made the direction we have to take very clear and sharp. We can now test for drugs that would regulate this protein pathway or optimize it, so it functions as it should in a normal state."

The announcement of the breakthrough is in Monday's issue of the research journal Nature. The paper lists 23 contributing scientists, including the lead authors, Northwestern neurological researchers Han-Xiang Deng and Wenjie Chen, and Siddique as senior author.

ALS afflicts about 30,000 Americans. With no known treatment for the paralysis, 50 percent of all ALS patients die within three years.

It is particularly tragic because it often strikes people who are very physically active. In 1941, New York Yankee baseball superstar Lou Gehrig died at 37 of the disease that now carries his name.2008-07-22 18.51.33

Amelie Gubitz, a research program director at the National Institute of Neurological Disorders and Stroke, said the Northwestern research is a big step forward in efforts worldwide to conquer ALS.

"You need to understand at the cellular level what is going wrong," said Gubitz. "Then you can begin to design drugs.

"ALS is a complicated problem, and Dr. Siddique's research adds a big piece to the puzzle that gives us important new insights."

A variety of proteins perform different functions within cells, and Deng and Chen led research that discovered a key protein, ubiquilin2, in the ALS mystery.

Ubiquilin2 in spinal and brain system cells is supposed to repair or dispose of other proteins as they become damaged. The researchers discovered a breakdown of this function in ALS patients.

When Ubiquilin2 is unable to remove or repair damaged proteins, the damaged proteins begin to pile up in the cells, eventually blocking normal transmission of brain signals in the spinal cord and brain, leading to paralysis.

There are three forms of ALS: "familial," which is hereditary and passed through genes; nonhereditary, which is called "sporadic"; and ALS that targets the brain, called "ALS/dementia."

Siddique was part of a study that made a breakthrough in ALS in the early 1990s, discovering the "familial" gene that causes the disease within some families. That breakthrough came after he began an ongoing study 25 years ago of an East Coast family that has lost more than 20 members to ALS.

Joanne Saltzman, a 72-year-old member of that family, recalled last week how she first learned of ALS when she was a small girl and her father, a naval veteran, was dying of the disease. Her grandfather died of it, too, as did four of her father's seven brothers.

Subsequently, one of Saltzman's sisters and many of her cousins died from ALS. It killed her 51-year-old son last October, she said in a phone interview, and in February her 52-year-old niece died of it.

"I am so excited by their new findings," Saltzman said of the Northwestern study. "Dr. Siddique has been studying our family for 25 years, and it is so encouraging for our remaining family."

"I told Dr. Siddique's office, if I could cut off my arm and send it to them I would if it would help them in the research," she said. "I would do anything. It is so important to me to be able to find some kind of cure for this awful disease."

ALSA overwhelmed by Ice Bucket campaign :-)

082314churchbucket

In the couple of hours it took an official from the ALS Association to return a reporter's call for comment, the group's ubiquitous "Ice Bucket Challenge" had brought in a few million more dollars.

Approaching $110 million, the viral fundraising campaign for the ailment also known as Lou Gehrig's Disease has put the ALS group into the top ranks for medical charity donations. Since the end of July, the money has been sloshing in at a rate of about $9 million a week. Last year, from July 29 to Aug. 26, the group raised just $2.6 million.

It's caught everyone off guard, none more so than the ALS Association folks. But they know this is likely a one-off phenomenon, and the group now faces the task of spending all that money wisely. Research, care and advocacy are the group's three main missions - but officials say they don't know yet exactly how they'll use the astonishing windfall.

"I think even if I or any PR person at either a non-profit or a for-profit company had all of the PR dollars in the world to invest, no one would have come up with this idea," said Carrie Munk, the association's spokeswoman. "We realize there are responsibilities that come with being good stewards of these dollars."

Part of what's surprising is that ALS - or amyotrophic lateral sclerosis - is one of those "orphan" diseases. It is a neurodegenerative disease that causes paralysis and death, and the association estimates that about 5,600 new cases are diagnosed in the U.S. each year.

This campaign hasn't exactly put the charity in the same neighborhood as giants like the American Cancer Society, the American Heart Association or Susan G. Komen for the Cure - which raised $889 million, $529 million and $310 million last year, respectively. But it's moving into the same ZIP code now.

"People who have been in this space for a long period of time feel like it's a dream come true," says Munk.

In case you've been under the proverbial rock, here are the basic rules: Someone issues a challenge - that you allow yourself to be doused with a bucket of ice and water, like winning coaches along the sidelines. Then, the challengee has 24 hours to make a $100 donation to the ALS Association or submit to the water torture.

In the last month, everyone from Microsoft co-founder Bill Gates to former President George W. Bush has been doused. The Internet and airwaves are awash in videos of people taking the challenge - even if they fully intend to write the check.

Jonah Berger, author of the book "Contagious: Why Things Catch On," says it's like a modern-day chain letter - except, in this case, everyone will know if you break the chain.

"It has a lot of the key ingredients that often make people want to share things," said Berger, a marketing professor at the University of Pennsylvania's Wharton School. "It gives people lots of social currency to be part of it. It makes you look good. It makes you look smart and in the know - you know what's going on. And it's always hard to back down from a challenge."

And now others are co-opting the bucket challenge for their own causes.

Actor Matt Damon, for instance, dumped toilet water over his head to call attention to his passion - safe drinking water. Actor Orlando Jones of the television series "Sleepy Hollow" showered himself with bullets in the wake of black teenager Michael Brown's shooting death by a white police officer in Ferguson, Mo.

"I'm challenging myself to listen without prejudice, to love without limits and to reverse the hate," he said. "So that's my challenge - to me. And, hopefully, you'll accept this challenge, too."

The Chronicle of Philanthropy says the ALS Association has, in this short period of time, raised more than many of the charities included on its Philanthropy 400 list.

"Right now, we're really focused on reaching out to and acknowledging and thanking the over 2 million donors that have come to the ALS Association," said Munk, the association spokeswoman. "And also working to put a process in place to make the best decisions to spend these dollars."

The American Institute of Philanthropy's CharityWatch gave the group a B+ rating for spending about 73 percent of its cash budget on programs. Analyst Stephanie Kalivas has no reason to believe that rating will need to be downgraded.

"We will definitely be keeping an eye out for them," she said. "Hopefully, they won't be wasteful with it."

Dr. Richard Bedlack, who runs the ALS clinic at the Duke Institute for Brain Sciences in Durham, N.C., knows how he would allocate the money. While the temptation might be to plow it all into the search for a cure, he says the biggest strides have been made in patient care and quality of life, and that would be his No. 1 priority.

"The chances of one of these research studies really finding meaningful disease-modifying therapy is very small," he says. "We're shooting in the dark. So, of course we've got to keep trying. But the bottom line is we've got to understand this disease better before we're going to be able to fix it in most people."

Wednesday, June 18, 2014

Researchers discover how ALS spreads

A study led by University of British Columbia and Vancouver Coastal Health Research Institute researchers has revealed how the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is transmitted from cell to cell, and suggests the spread of the disease could be blocked.

iStock_000025129879XSmall-300x194

"This work identifies an important piece of the puzzle in determining how the disease is transmitted throughout the nervous system," says lead investigator Dr. Neil Cashman, UBC's Canada Research Chair in Neurodegeneration and Protein Misfolding. "By understanding how this occurs, we can devise the best ways to stop the progressive neurological damage seen in ALS."

The research shows that misfolded non-mutant SOD1 can be transmitted from region to region in the nervous system, offering a molecular explanation for the progressive spread of ALS.

Published today in the Proceedings of the National Academy of Sciences, the study also shows the spread can be blocked using antibodies. Antibodies were specifically raised to bind to regions of SOD1 exposed when it is misfolded, and block its spread. If non-mutant SOD1 misfolding is the cause of ALS, as the study suggests, then the antibodies could arrest ALS progression, the researchers say.

This work builds on previous research in Cashman's lab. ALS is associated with the mutant SOD1 protein (superoxide dismutase 1) and earlier investigations found that the disease-associated mutant SOD1 can induce a change in the shape of other proteins at the molecular level by misfolding inside living cells. The affected proteins then accumulate in ways similar to the process underlying prion diseases – rare, fatal, degenerative brain disorders seen in both humans and animals.

ALS is a disease that affects nerve cells in the brain and the spinal cord. Motor neurons progressively degenerate and die so that the brain can no longer initiate and control muscle movement. Patients in the later stages of the disease may become totally paralyzed. There are approximately 140,000 new cases diagnosed worldwide each year.

###

Background:

Dr. Neil Cashman is Professor and Canada Research Chair in Neurodegeneration and Protein Misfolding at UBC, and Academic Director of the Vancouver Coastal Health ALS Centre. He is also a member of the Brain Research Centre, a partnership between UBC and Vancouver Coastal Health Research Institute.

Prion disease:

Prion diseases belong to the general category of brain diseases called proteinopathies, which also includes Alzheimer's disease and Parkinson's disease. The most common human form of prion disease is Creutzfeldt-Jakob disease (CJD).

Prion diseases of animals include Bovine Spongiform Encephalopathy (BSE) (mad cow disease) in cattle, scrapie in sheep and goats, and Chronic Wasting Disease (CWD) in deer and elk.

Additional links:

Vancouver Coastal ALS Centre: http://www.vch.ca/403/7676/?program_id=952

Brain Research Centre: http://brain.ubc.ca

Tuesday, April 29, 2014

FDA okays start of BrainStorm stem cell trial in ALS patients

BrainStorm Cell Therapeutics said the U.S. Food and Drug Administration approved the start of a mid-stage clinical trial of its adult stem cell treatment for patients with amyotrophic lateral sclerosis (ALS).

The Phase II trial will be MSC-NTFlaunched initially at Massachusetts General Hospital in Boston and the University of Massachusetts Memorial Hospital in Worcester.

Dana-Farber Cancer Institute's Connell O'Reilly Cell Manipulation Core Facility will manufacture BrainStorm's NurOwn cells for these two clinical sites. The trial will also be conducted at the Mayo Clinic, the Israel-based company said on Sunday. The trials are expected to start soon.

http://www.brainstorm-cell.com/index.php/science-a-technology/-nurown

"Today's announcement represents the most significant milestone BrainStorm has achieved to date," the company's president, Chaim Lebovits, said.

This trial will be the first Phase II double-blinded stem cell study to be conducted for ALS, he added.

ALS, also known as Lou Gehrig's Disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord.

BrainStorm's Phase II trial is designed to evaluate the safety and efficacy of transplantation of the stem cells in 48 ALS patients. The cells will be administered via intramuscular and intrathecal injection.

Patients will be followed monthly for three months before transplantation and for six months following transplantation.

Earlier clinical trials have shown that treatment with NurOwn cells was well tolerated and safe.

Last week, Cytokinetics Inc said its experimental treatment for Lou Gehrig's Disease failed the main goal in a mid-stage trial.

Sunday, March 02, 2014

NEOWISE Finds Its First Comet On February 14

NEOWISE Finds Its First Comet On February 14

March 1, 2014

Image Caption: Comet NEOWISE was first observed by NASA's Near-Earth Object Wide-field Infrared Survey Explorer (NEOWISE) spacecraft on Valentine's Day, 2014. Credit: NASA/JPL-Caltech

NASA’s Near-Earth Object Wide-field Infrared Survey Explorer (NEOWISE) spacecraft has spotted a never-before-seen comet – its first such discovery since coming out of hibernation late last year.

“We are so pleased to have discovered this frozen visitor from the outermost reaches of our solar system,” said Amy Mainzer, the mission’s principal investigator from NASA’s Jet Propulsion Laboratory in Pasadena, Calif. “This comet is a weirdo – it is in a retrograde orbit, meaning that it orbits the sun in the opposite sense from Earth and the other planets.”

Officially named “C/2014 C3 (NEOWISE)”, the first comet discovery of the renewed mission came on Feb. 14 when the comet was about 143 million miles (230 million kilometers) from Earth. Although the comet’s orbit is still a bit uncertain, it appears to have arrived from its most distant point in the region of the outer planets. The mission’s sophisticated software picked out the moving object against a background of stationary stars. As NEOWISE circled Earth, scanning the sky, it observed the comet six times over half a day before the object moved out of its view. The discovery was confirmed by the Minor Planet Center, Cambridge, Mass., when follow-up observations were received three days later from the Near Earth Object Observation project Spacewatch, Tucson, Ariz. Other follow-up observations were then quickly received. While this is the first comet NEOWISE has discovered since coming out of hibernation, the spacecraft is credited with the discovery of 21 other comets during its primary mission.

Originally called the Wide-field Infrared Survey Explorer (WISE), the spacecraft was shut down in 2011 after its primary mission was completed. In September 2013, it was reactivated, renamed NEOWISE and assigned a new mission to assist NASA’s efforts to identify the population of potentially hazardous near-Earth objects. NEOWISE will also characterize previously known asteroids and comets to better understand their sizes and compositions.

JPL manages the NEOWISE mission for NASA’s Science Mission Directorate in Washington. The Space Dynamics Laboratory in Logan, Utah, built the science instrument. Ball Aerospace & Technologies Corp. of Boulder, Colo., built the spacecraft. Science operations and data processing take place at the Infrared Processing and Analysis Center at the California Institute of Technology in Pasadena. Caltech manages JPL for NASA.

More information on NEOWISE is online at: http://www.jpl.nasa.gov/wise/

Friday, February 28, 2014

ALS may be slowed by a diet rich in calories and carbohydrates…

A diet rich in calories and carbohydrates may slow progression of the lethal, degenerative Lou Gehrig's disease, according to a small-scale study reported in The Lancet on Friday.

PARIS: A diet rich in calories and carbohydrates may slow progression of the lethal, degenerative Lou Gehrig's disease, according to a small-scale study reported in The Lancet on Friday.

Formally called amyotrophic lateral sclerosis (ALS) or motor neuron disease, the disorder affects nerve cells that control muscle movement.

Patients become tired and weak and lose the power to move and eventually breathe; they die three years on average after being diagnosed.

The new study follows up on suspicions that ALS patients may be placed at even greater risk if they lose weight. They find it hard to eat and swallow, and eventually have to be fed with a tube directly into the stomach.

Experiments on mice genetically engineered to display ALS symptoms have found that those given a high-calorie diet rich in fat survived longer.

Building on this work, researchers in the United States tested 20 volunteers with advanced ALS who were at the stage of being tube-fed.

The patients were divided into three groups.

One was a "control" group which received a nutritional formula designed to keep their weight stable, while the other two received 125 percent of the calories they needed to maintain their weight.

Of these two groups, one received a high-calorie diet rich in carbohydrates, and the other a high-calorie diet rich in fats.

The diets lasted for four months, and patients were followed for a further five months afterwards.

Patients on the diet that was high in calories and carbs did far better than counterparts in the two other groups, the researchers found.

They experienced fewer "adverse events" -- health problems ranging from pneumonia to muscular pains or rashes.

They also gained more weight, picking up 390g per month on average, compared to a gain of 110g in the control group and a loss of 460g in the high-calorie high-fat diet group.

During the five-month follow-up, no deaths occurred among the high-calorie, high-carbohydrate group, compared with one in the high-fat group and three in the control group, said the study.

The experiment was only conducted on a small scale and its chief goal had been to see whether ALS patients could safely change diet, rather than testing how effective the switch might be.

"This pilot study demonstrates the safety of a novel, simple, low-cost treatment for a devastating disease where currently very few treatment options are available," said lead researcher Anne-Marie Wills at the Massachusetts General Hospital in Boston.

"The adverse outcomes that we feared might result from weight gain, such as diabetes or heart disease, were not observed in our study period."

The team called for larger trials among patients at an earlier stage of ALS, to see whether these optimistic but cautious findings hold true.

Sunday, September 01, 2013

My Program from Ball Aerospace is Reignited

WISE reactivated to hunt for asteroids

(2009-08-05) New Pics 039I worked on this spacecraft during my years at Ball as the Mission Assurance Manager. That’s me with WISE on the right.

The spacecraft will assist in efforts to identify the population of potentially hazardous near-Earth objects, as well as those suitable for asteroid exploration missions.

 

This artist's concept shows the Wide-field Infrared Survey Explorer (WISE) spacecraft in its orbit around Earth. In September of 2013, engineers will attempt to bring the mission out of hibernation to hunt for more asteroids and comets in a project called NEOWISE.

Wide-field Infrared Survey Explorer

A NASA spacecraft that discovered and characterized tens of thousands of asteroids throughout the solar system before being placed in hibernation will return to service for three more years starting in September, assisting the agency in its effort to identify the population of potentially hazardous near-Earth objects, as well as those suitable for asteroid exploration missions.
The Wide-field Infrared Survey Explorer (WISE) will be revived next month with the goal of discovering and characterizing near-Earth objects (NEOs), space rocks that can be found orbiting within 28 million miles (45 million kilometers) of Earth’s path around the Sun. NASA anticipates WISE will use its 16-inch (40 centimeters) telescope and infrared cameras to discover about 150 previously unknown NEOs and characterize the size, albedo, and thermal properties of about 2,000 others, including some that could be candidates for the agency’s recently announced asteroid initiative.
“The WISE mission achieved its mission’s goals and as NEOWISE extended the science even further in its survey of asteroids. NASA is now extending that record of success, which will enhance our ability to find potentially hazardous asteroids and support the new asteroid initiative,” said John Grunsfeld, NASA’s associate administrator for science in Washington, D.C. “Reactivating WISE is an excellent example of how we are leveraging existing capabilities across the agency to achieve our goal.”
NASA’s asteroid initiative will be the first mission to identify, capture, and relocate an asteroid. It represents an unprecedented technological feat that will lead to new scientific discoveries and technological capabilities that will help protect our home planet. The asteroid initiative brings together the best of NASA’s science, technology, and human exploration efforts to achieve President Obama’s goal of sending humans to an asteroid by 2025.
Launched in December 2009 to look for the glow of celestial heat sources from asteroids, stars, and galaxies, WISE made about 7,500 images every day during its primary mission from January 2010 to February 2011. As part of a project called NEOWISE, the spacecraft made the most accurate survey to date of NEOs. NASA turned most of WISE’s electronics off when it completed its primary mission.
“The data collected by NEOWISE two years ago have proven to be a gold mine for the discovery and characterization of the NEO population,” said Lindley Johnson, NASA’s NEOWISE program executive in Washington, D.C. “It is important that we accumulate as much of this type of data as possible while the WISE spacecraft remains a viable asset.”
Because asteroids reflect but do not emit visible light, infrared sensors are a powerful tool for discovering, cataloging, and understanding the asteroid population. Depending on an object’s reflectivity, or albedo, a small light-colored space rock can look the same as a big dark one. As a result, data collected with optical telescopes using visible light can be deceiving.
During 2010, NEOWISE observed about 158,000 rocky bodies out of approximately 600,000 known objects. Discoveries included 21 comets, more than 34,000 asteroids in the main belt between Mars and Jupiter, and 135 near-Earth objects.
The WISE prime mission was to scan the entire celestial sky in infrared light. It captured more than 2.7 million images in multiple infrared wavelengths and cataloged more than 560 million objects in space, ranging from faraway galaxies to asteroids and comets much closer to Earth.
“The team is ready, and after a quick checkout, we’re going to hit the ground running,” said Amy Mainzer from NASA’s Jet Propulsion Laboratory in Pasadena, California. “NEOWISE not only gives us a better understanding of the asteroids and comets we study directly, but it will help us refine our concepts and mission operation plans for future space-based near-Earth object cataloging missions.”

By Jet Propulsion Laboratory, Pasadena, California, NASA Headquarters, Washington, D.C. — Published: August 22, 2013

Wednesday, August 21, 2013

Letter to President Obama on Surveillance and Freedom

Copyright by http://benlog.com

Posted on August 19, 2013 by benadida

I fully agree!!!!!

=============================================

Dear President Obama,

My name is Ben Adida. I am 36, married, two kids, working insnowden Silicon Valley as a software engineer with a strong background in security. I’ve worked on the security of voting systems and health systems, on web browsers and payment systems. I enthusiastically voted for you three times: in the 2008 primary and in both presidential elections. When I wrote about my support for your campaign five years ago, I said:

In his campaign, Obama has proposed opening up to the public all bill debates and negotiations with lobbyists, via TV and the Internet. Why? Because he trusts that Americans, when given the tools to see and understand what their legislators are doing, will apply pressure to keep their government honest.

I gushed about how you supported transparency as broadly as possible, to enable better decision making, to empower individuals, and to build a better nation.

Now, I’m no stubborn idealist. I know that change is hard and slow. I know you cannot steer a ship as big as the United States as quickly as some would like. I know tough compromises are the inevitable path to progress.

I also imagine that, once you’re President, the enormity of the threat from those who would attack Americans must be overwhelming. The responsibility you feel, the level of detail you understand, must make prior principles sometimes feel quaint. I cannot imagine what it’s like to be in your shoes.

I also remember that you called on us, your supporters, to stay active, to call you and Congress to task. I want to believe that you asked for this because you knew that your perspective as Commander in Chief would inevitably become skewed. So this is what I’m doing here: I’m calling you to task.

You are failing hard on transparency and oversight when it comes to NSA surveillance. This failure is not the pragmatic compromise of Obamacare, which I strongly support. It is not the sheer difficulty of closing Guantanamo, which I understand. This failure is deep. If you fail to fix it, you will be the President principally responsible for the effective death of the Fourth Amendment and worse.

mass surveillance

The specific topic of concern, to be clear, is mass surveillance. I am not concerned with targeted data requests, based on probable cause and reviewed individually by publicly accountable judges. I can even live with secret data requests, provided they’re very limited, finely targeted, and protect the free-speech rights of service providers like Google and Facebook to release appropriately sanitized data about these requests as often as they’d like.

What I’m concerned about is the broad, dragnet NSA signals intelligence recently revealed by Edward Snowden. This kind of surveillance is a different beast, comparable to routine frisking of every individual simply for walking down the street. It is repulsive to me. It should be repulsive to you, too.

wrong in practice

If you’re a hypochondriac, you might be tempted to ask your doctor for a full body MRI or CT scan to catch health issues before detectable symptoms. Unfortunately, because of two simple probabilistic principles, you’re much worse off if you get the test.

First, it is relatively unlikely that a random person with no symptoms has a serious medical problem, ie the prior probability is low. Second, it is quite possible — not likely, but possible — that a completely benign thing appears potentially dangerous on imaging, ie there is a noticeable chance of false positive. Put those two things together, and you get this mind-bending outcome: if the full-body MRI says you have something to worry about, you actually don’t have anything to worry about. But try convincing yourself of that if you get a scary MRI result.

Mass surveillance to seek out terrorism is basically the same thing: very low prior probability that any given person is a terrorist, quite possible that normal behavior appears suspicious. Mass surveillance means wasting tremendous resources on dead ends. And because we’re human and we make mistakes when given bad data, mass surveillance sometimes means badly hurting innocent people, like Jean-Charles de Menezes.

So what happens when a massively funded effort has frustratingly poor outcomes? You get scope creep: the surveillance apparatus gets redirected to other purposes. The TSA starts overseeing sporting events. The DEA and IRS dip into the NSA dataset. Anti-terrorism laws with far-reaching powers are used tointimidate journalists and their loved ones.

Where does it stop? If we forgo due process for a certain category of investigation which, by design, will see its scope broaden to just about any type of investigation, is there any due process left?

wrong on principle

I can imagine some people, maybe some of your trusted advisors, will say that what I’ve just described is simply a “poor implementation” of surveillance, that the NSA does a much better job. So it’s worth asking: assuming we can perfect a surveillance system with zero false positives, is it then okay to live in a society that implements such surveillance and detects any illegal act?

This has always felt wrong to me, but I couldn’t express a simple, principled, ethical reason for this feeling, until I spoke with a colleague recently who said it better than I ever could:

For society to progress, individuals must be able to experiment very close to the limit of the law and sometimes cross into illegality. A society which perfectly enforces its laws is one that cannot make progress.

What would have become of the civil rights movement if all of its initial transgressions had been perfectly detected and punished? What about gay rights? Women’s rights? Is there even room for civil disobedience?

Though we want our laws to reflect morality, they are, at best, a very rough and sometimes completely broken approximation of morality. Our ability as citizens to occasionally transgress the law is the force that brings our society’s laws closer to our moral ideals. We should reject mass surveillance, even the theoretically perfect kind, with all the strength and fury of a people striving to form a more perfect union.

patriots

Mr. President, you have said that you do not consider Edward Snowden a patriot, and you have not commented on whether he is a whistleblower. I ask you to consider this: if you were an ordinary citizen, living your life as a Law Professor at the University of Chicago, and you found out, through Edward Snowden’s revelations, the scope of the NSA mass surveillance program and the misuse of the accumulated data by the DEA and the IRS, what would you think? Wouldn’t you, like many of us, be thankful that Mr. Snowden risked his life to give we the people this information, so that we may judge for ourselves whether this is the society we want?

And if there is even a possibility that you would feel this way, given that many thousands do, if government insiders believe Snowden to be a traitor while outsiders believe him to be a whisteblower, is that not all the information you need to realize the critical positive role he has played, and the need for the government to change?

the time to do something is now

I still believe that you are, at your core, a unique President who values a government by and for the people. As a continuing supporter of your Presidency, I implore you to look deeply at this issue, to bring in outside experts who are notinvolved in national security. This issue is critical to our future as a free nation.

Please do what is right so that your daughters and my sons can grow up with the privacy and dignity they deserve, free from surveillance, its inevitable abuses, and its paralyzing force. Our kids, too, will have civil rights battles to fight. They, too, will need the ability to challenge unjust laws. They, too, will need the space to make our country better still.

Please do not rob them of that opportunity.

Sincerely,

Ben Adida

Monday, August 12, 2013

Jason Becker: Rock star at 16, ALS at 19

Jason Becker cut an album with David Lee Roth. The same year, he was diagnosed with ALS and given 3-5 years to livejbecker_s640x427 Photo: jasonbeckerguitar.com
Monday, August 12, 2013 - Steps to Authentic Happiness via Positive Psychology by Paul Mountjoy

Jason Becker: Guitar phenom, writer and ALS survivor

WASHINGTON- AUGUST 11. 2013 — Jason Becker became a guitarist at the age of five. At the age of 16, he started a band called Cacaphony with lifelong friend and future guitarist for Megadeth, Marty Friedman. At age 19, Becker cut an album with David Lee Roth of Van Halen fame. Also at 19, Becker was diagnosed with amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s disease. Becker was given three to five years to live.

ALS slowly robs every aspect of your physicality piece by piece until the only moveable parts are your eyes. For most, death happens within three to five years from diagnosis because ALS is a neurodegenerative disease that is very aggressive. ALS affects the nerve cells in the brain and spinal cord but does not affect what is known as the involuntary body functions such as the heart and digestive system but may cause death from respiratory failure. Complete paralysis is unavoidable.

The cause of ALS in unknown and the experience with this disease varies from one person to the next and there are clinical trials that hold promise yet there are 5,600 new cases of ALS every year and can strike anyone at any time. Becker is among the five percent that lives beyond 20 years with this disease.

Today, Becker is 44 years old.  He recently released a documentary called Not Dead Yet and currently writes music with his eyes on a system developed by his Father. The Washington Times caught up with the busy Becker who took time to discuss his life with ALS:

Paul Mountjoy: You noticed your first symptom at age 19. What as it?

Jason Becker: My folks had gone away for Mother’s Day. I was sleeping with my girlfriend and a really painful cramp in my left leg woke me up. I jumped out of bed and tried to work it out. It never quite went away no matter how much I exercised it. It became a lazy feeling in my leg.

SEE RELATED: Jason Becker: Guitar phenom, writer and ALS survivor

PM: What was the progression and time frame?

JB: That’s a little tough to remember. I went on tour with Cacaphony the following summer (1989) and I was feeling a little bit tired. Yet I thought it would go away. Sometimes my left toes would drag the ground. I did not go to the hospital to check it out until I moved to LA in November to play with David Lee Roth. I was getting tired of tripping on myself. I was diagnosed with ALS that same month.

I started feeling the weakness in my left hand while recording “A Little Ain’t Enough” with Roth in Vancouver I was having trouble with an easy part. I looked at my hand and noticed the muscle between my thumb and first finger was practically gone. I was able to finish the album but I could not go on tour because I was getting too weak in my whole body.

PM: What did you think when the doctors told you of ALS and your 3-5 year prognosis?

JB: I didn’t think much. I thought “Can I go now?” I have to go play guitar and practice with Roth now. You must understand how strong I am. I will get rid of this annoying little inconvenience.

PM: Had you heard of ALS before?

JB: No, I hadn’t and I didn’t even look it up. My folks did but I told them not to tell me anything when the doctors told me I had three to five years to live, I didn’t believe them at all.

PM: Were you frightened?

JB: I don’t remember being frightened, but I’m sure I was scared somewhere inside me. I just tried to keep it out of my mind. I had music to make! Also, I didn’t want my family to worry. I wanted them to see me happy. I was very happy, but if I got sad, I hid it.

PM: How did those around you act?

JB: My parents freaked out. They tried to hide it from me but whenever I was out, they constantly cried. They helped me with everything but they were dying inside. My friends were great. They were chill (sic) yet supportive. I think my Mom cried every day for ten years. Steve Hunter (Alice Cooper guitarist) had my back in Vancouver. He would give me B-12 shots between joking around, recording and having a blast. Roth offered his Dad, who was a doctor, to do anything I needed. Everyone was awesome; even the stripper I was hanging out with offered to be ‘on the bottom’.

PM: What point are you at now and what are your expectations?

JB: I am relatively stable. Can’t move S**t except for some of my face and a couple other muscles and my sex life is fine! I try to not get sick because it could make me weaker.

I don’t have any expectations. I just want to do my best with whatever I am given. If they find a cure, awesome but if not, that is OK. I have had a great life.

Hey, when I finally do croak, I forbid anyone to be sad. Everyone should celebrate a cool life! I had a blast!

PM: Being that Steven hawking has had ALS for 50 ears, does this give you hope?

JB: Oh, I guess. I don’t think about that much. I am too busy doing other stuff.

PM: Do you sleep alright?

JB: Usually great.

PM: As many do with such when struck by such disease, do you dream of walking or running?

JB: Yes. I never dream I am sick. I am always totally healthy. All of my family, friends and ladies always dream I am healthy or at least becoming healthy. Only one woman dreamed she was having sex with me in this situation. That was really cool, actually.

PM: You are musician with unlimited potential. Do you feel more fortunate than those without such potential and do you advise folks to find a potential and work it?

JB: HMMMMM- Good question. I don’t think like that. I feel very lucky to be passionate about music but that isn’t everyone’s thing. It is definitely awesome having a passion and I wish that for everyone. I don’t feel qualified to give much advice but if I did, that would be great advice.

PM: Aside from your limitations, would you say you are happy?

JB: Mostly, definitely yes, even with my limitations. I get depressed, sad and angry sometimes, too.

PM: What would you advise others in your situation?

JB: Well, there is more to life than just moving, but it depends on how much help and love you get. I couldn’t continue if I didn’t have help form people no matter how much I wanted to. People who know someone with ALS should help them as much as they can.

PM: Any stem cell hope?

JB: Sure! Fans often send me updates of possible treatments from all over the world.

Jason Becker is a remarkable man. His personality is a primary reason he is so popular among his loved ones and fans. His parents are devoted and give Jason all they can. He is surrounded by love and appreciates every minute of it and takes nothing for granted. It seems these traits were constructs of his personality before he contracted ALS.

Any time anyone has a reason to be lazy and unproductive, just think: “I know Jason would love to able to do this chore, goal or whatever,” then get to it. He inspires and motivates us all.

For more on Jason Becker, go to jasonbeckerguitar.com

Read more: http://communities.washingtontimes.com/neighborhood/steps-authentic-happiness-positive-psychology/2013/aug/12/rock-star-16-als-lou-gehrigs-disease-19/#ixzz2bouwDvPE
Follow us: @wtcommunities on Twitter

Saturday, July 06, 2013

ALS: Misfolded TDP43 Appears to Spread

ALS: Misfolded TDP43 Appears to Spread

In amyotrophic lateral sclerosis, abnormal clumps containing the TDP43 protein may originate in one part of brain or spinal cord and spread to other parts

Article Highlights:27.b

  • A study of brain and spinal cord tissues taken from people with amyotrophic lateral sclerosis (ALS) suggests that the disease may spread through interconnected regions of the brain and spinal cord in a sequential pattern the investigators divided into four stages.
  • Affected areas are marked by the presence of protein clumps containing toxic TDP43 protein.
  • Spread of the toxic TDP43 protein from one region to another appears to occur by cell-to-cell transmission via nerve-cell fibers (axons).
  • If confirmed, the findings may point toward new strategies for treatments aimed at halting the spread of the disease.
To learn more, read the full ALS News Online article.

Tuesday, May 07, 2013

Struggles with Nursing and Care Costs $$$$


Originally by Milton D. Carrero, Of The Morning Call

Former Northwestern Lehigh High School football standout Brett Snyder has been fighting Lou Gehrig's disease for the past decade, but that's not his only challenge.

He recently underwent a tracheotomy and needs a ventilator, which means that speech as he once knew it is now another one of his memories. The 35-year-old communicates through a machine that detects his eye movements. He blinks to type his thoughts into a keyboard. That is still not his greatest challenge.

His greatest challenge is that NURSINGhe needs 24-hour nursing care, and his main obstacle seems to be government bureaucracy and laws that make it harder on the middle class.

"The biggest problem is care," Snyder says. "The care we qualify for we can't get, and the care we need we don't qualify until we go bankrupt."
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The Macungie family is not wealthy enough to afford a full-time nurse to help with his daily physical and medical needs. And the program that provides assistance to pay for these services says they earn too much to qualify.

Sound familiar? Welcome to what Snyder's wife Carissa calls the American health care black hole, which increases an already immense burden.

"I love my family," Snyder says. "Every morning when I wake up, I can't wait to see my wife and son. But at the same time, I see the burden that I am putting on them. Not having enough caretakers is awful."

It puts an additional stress on everyone in the family.

"When a family goes through something like this," Carissa Snyder says, "it's so overwhelming, all-encompassing, that it takes every ounce that you have just to cope."

She laments not having more time to advocate for changes in the criteria used to qualify for government health assistance programs.

Time is a valuable asset for this couple, and enduring the impact of a debilitating disease is burden enough.

"I won't give up," Snyder says. "I am also very grateful for the love and support of my friends and family, and my wife has been my angel."

This couple need a few angels in Congress to change the laws. In the meantime, if you think you can help this family, contact http://www.facebook.com/prayforbrett

 

NEW BLOGS TO FOLLOW


Living with ALS by Tom Swift

No More Nursing Home Blues

http://livingwithalsbytomswift.blogspot.com/2011/08/no-more-nursing-home-blues.html


Medicare to Cover More Home Health Services

Posted by Rambling Man of ALS on February 8, 2013 in ALS, ALS - Research, Did You Know, Political

http://ramblingmanofals.com/2013/02/08/medicare-to-cover-more-home-health-services/

Wednesday, April 10, 2013

Stephen Hawking Visits LA Stem-Cell Lab

Stephen Hawking toured a stem cell laboratory Tuesday where scientists are studying ways to slow the progression of Lou Gehrig's disease, a neurological disorder that has left the British cosmologist almost completely paralyzed.

After the visit, the 71-year-old Hawking urged doctors, nurses and staff at Cedars-Sinai Medical Center to support the research.

Hawking recalled how he became depressed when he was diagnosed with the disease 50 years ago and initially didn't see a point in finishing his doctorate. But his attitude changed when his condition didn't progress quickly and he was able to concentrate on his studies.

"Every new day became a bonus," he told a packed room.

89761022Cedars-Sinai received nearly $18 million last year from California's taxpayer-funded stem cell institute to study the debilitating disease also known as amyotrophic lateral sclerosis. ALS attacks nerve cells in the brain and spinal cord that control the muscles. People gradually have more and more trouble breathing and moving as muscles weaken and waste away.

There's no cure and no way to reverse the disease's progression. Few people with ALS live longer than a decade.

Diagnosed at age 21 while a student at Cambridge University,blog-BigBangTheory-StephenHawking Hawking has survived longer than most. He receives around-the-clock care, can only communicate by twitching his cheek, and relies on a computer mounted to his wheelchair to convey his thoughts in a distinctive robotic monotone.

A Cedars-Sinai patient who was Hawking's former student spurred doctors to invite the physicist to glimpse their stem cell work.

"We decided it was a great opportunity for him to see the labs and for us to speak to one of the preeminent scientists in the world," said Dr. Robert Baloh, who heads the hospital's ALS program.

During the tour, Hawking viewed microscopic stem cells through a projector screen and asked questions about the research, Baloh said.

Cedar-Sinai scientists have focused on engineering stem cells to make a protein in hopes of preventing nerve cells from dying. The experiment so far has been done in rats. Baloh said he hopes to get governmental approval to test it in humans, which would be needed before any therapy can be approved.

Renowned for his work on black holes and the origins of the universe, Hawking is famous for bringing esoteric physics concepts to the masses through his best-selling books including "A Brief History of Time," which sold more than 10 million copies worldwide. Hawking titled his speech to Cedars-Sinai employees "A Brief History of Mine."

Saturday, March 16, 2013

My Top 18 Drummers List

“My” Top 10 turned into 18+ Drummers List and I still don’t have it right…. except for the top 4!

I played from age 10 to 41 before ALS forced me to quit. One of the hardest things ever for me to lose! More than driving, skiing or sometimes even speech. First I played trashcans and buckets in 1975. Then, I had a 1977 red sparkle set and later Pearl, Tama, Paiste and Zildjian kit which expanded to 5 cymbals and 6 drums over the years through 1989. Then in 2005, I bought a Roland V-Drum TD-20 kit. My son has now been playing for 7 years using acoustics, but mainly the electronic set. He’s playing to music with headphones on just like I did 30+ yrs ago…


#1 Neil Peart

My drumming IDOL !

https://www.youtube.com/watch?v=ffbopIER3ks at 5:20 in


#2 Buddy Rich

http://youtu.be/9esWG6A6g-k

This is probably the best drum solo by Buddy Rich (or by anybody) when he was 53

https://www.youtube.com/watch?v=53cxGeeGFAU


#3 Mike Portnoy

Dream Theater

 

Mike Portnoy Drum Solo

Rush YYZ cover - Mike Portnoy


# 4 Thomas Lang

http://www.youtube.com/watch?v=_rT_mqPKVvA


#5 Chad Smith

Red Hot Chili Peppers
Red Hot Chili Peppers


#6 Dave Grohl

Blink 182

also: http://youtu.be/Z2qUO6k0F34


#7 Vic Firth


#8 Dylan Elise

Dylan Elise is a 16 year old drummer

also… http://youtu.be/ElYCb6G7gSk


#9 Alex Van Halen


#10 Virgil Donati


#11 Gene Krupa & Louie Bellson

Gene Krupa vs. Buddy Rich drum battle

http://youtu.be/BZ5B7yqDYbA

Drum Duel - Buddy Rich vs Louie Bellson

http://www.youtube.com/watchNR=1&v=CYSeHscZJPQ&feature=endscreen


#12 Taylor Hawkins

Foo Fighters



#13 Stewart Copeland


#14 Mike Mangini

http://www.youtube.com/watch?v=wou5tOt2vp8


#15 John Bonham

Led Zeppelin


#16 Mike Terrana


#17 Jimmy Chamberlin
of the Smashing Pumpkins

#18 Travis Barker



Or you choose

Drummers Compilation #1
Drummers Compilation #2

---------------

Just had to add a few more…

“Playing Drums with Mike Portnoy from Dream Theater”

Dream Theater "Mike Mangini Drum Solo"

“Guitar Center Drum-Off 2012 Finalist - Aric Improta”

Guitar Center Drum-Off 2012 Champion Juan Carlos Mendoza

“GoPro: Dave Matthews Band's Carter Beauford Drum Solo”